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1 December, 2025

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Technology
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Advances in Therapy
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Advances in Therapy
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Legends

Smart Doctor

Hot Topics – Issue 11 July 2025

We are on a mission to empower healthcare professionals, researchers, and medical enthusiasts with the latest insights, innovations, and opportunities in the ever-evolving world of medicine. Our passion lies in fostering a thriving community where ideas converge, knowledge is shared, and groundbreaking advancements are made possible through collective efforts.

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Psilocybin Therapy Improves Mood, Motor, and Cognitive Function in PD

The study’s single‑arm, open‑label pilot (NCT04932434) evaluated the safety, feasibility, and preliminary efficacy of psilocybin‑assisted therapy in 12 adults (mean

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Extended‑Half‑Life Clesrovimab Prevents RSV‑Associated Lower Respiratory Disease in Infants

This report summarizes pivotal trials underpinning the FDA approval of Enflonsia™ (clesrovimab‑cfor), an extended‑half‑life monoclonal antibody targeting the RSV fusion

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Intravenous Meloxicam Receives FDA Approval for Moderate–Severe Pain Management

This report summarizes the US Food and Drug Administration’s approval of Xifyrm™,a meloxicam intravenous formulation for adults requiring moderate to

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Maternal Prenatal Smoking Elevates Adolescent Hypertension Risk in Offspring

The longitudinal study quantified the impact of maternal smoking during pregnancy on blood pressure (BP) and hypertension in early adolescence.

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Psoriasis Severity Correlates with Elevated Sleep Disorder Risk in a Diverse Cohort

This retrospective, matched‑cohort study evaluated the relationship between psoriasis severity and specific sleep disorders using the All of Us registry.

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Soy-Based Vegan Diet Lowers Weight and Hot Flashes

The randomized, controlled trial investigated whether a low fat, soy supplemented vegan diet ameliorates weight and vasomotor symptoms in postmenopausal

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Dalpiciclib Plus Endocrine Therapy Improves Early HR+/HER2– Breast Cancer Outcomes

This phase 3 DAWNA‑A trial (NCT04842617) was conducted to determine whether adjuvant dalpiciclib enhances survival when combined with endocrine therapy

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Nadunolimab Plus Chemotherapy Improves Survival in IL1RAP‑High Metastatic PDAC

The study analysis evaluated the efficacy of nadunolimab— a fully humanized Fc enhanced IgG1 monoclonal antibody targeting interleukin 1 receptor

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Dostarlimab–Chemotherapy Improves Quality-Adjusted and Overall Survival in Endometrial Cancer

This randomized, double‑blind, placebo‑controlled trial assessed whether adding dostarlimab to standard carboplatin–paclitaxel chemotherapy improves quality‑adjusted and overall survival in primary

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Avacopan Reduces Adverse Events in ANCA-Associated Vasculitis Treatment

The pooled analysis aimed to evaluate the safety profile of avacopan, a complement C5a receptor inhibitor, in patients with antineutrophil

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AI in Clinical Decision-Making: Hype vs. Reality

Precision Nutrition: Tailoring Diets Based on Genetic and Microbiome Profiles