Icotrokinra Demonstrates Efficacy in Adolescent Plaque Psoriasis in ICONIC-LEAD Subgroup Analysis
The ICONIC-LEAD phase 3 trial (NCT06095115) evaluated the oral interleukin-23 inhibitor icotrokinra for treating moderate to severe plaque psoriasis in adolescents (≥12 years) and adults. A subgroup analysis of 66 adolescent patients revealed compelling results, with 84.1% of icotrokinra-treated adolescents achieving Investigator’s Global Assessment (IGA) scores of 0/1 (clear or almost clear skin), and 70.5% […]
Adjuvant Dabrafenib-Trametinib Shows Favorable Outcomes in Stage IIIA Melanoma
In a retrospective multicenter study, adjuvant dabrafenib plus trametinib demonstrated superior recurrence-free survival (RFS) and distant-metastasis-free survival (DMFS) compared to observation or anti-PD-1 therapy in patients with stage IIIA cutaneous melanoma. Published in Annals of Oncology, the analysis included 628 patients treated between 2018 and 2021 across Australia, Europe, and the U.S., with groups receiving […]
Endocrine Therapy Omission Linked to Worse Outcomes in ER-Low Early Breast Cancer
Omitting adjuvant endocrine therapy (ET) in patients with estrogen receptor (ER)-low (1%-10% by IHC) early-stage breast cancer may be associated with increased mortality, according to a retrospective analysis of 7018 women enrolled in the National Cancer Database. Most patients had aggressive tumor features, including grade 3 disease (74%), PR-negativity (73%), and HER2-negativity (65%). All underwent […]
Osteoporosis in Men: An Underdiagnosed Risk with Overlooked Consequences
Osteoporosis remains a largely underdiagnosed and undertreated condition in men, despite posing substantial morbidity and mortality risks. While commonly associated with postmenopausal women, men experience worse outcomes following fragility fractures, including twice the mortality risk after hip fractures. Nonetheless, osteoporosis screening rates in men remain low, often due to misconceptions and lack of guideline awareness. […]
Demographic Subgroup Analysis Confirms Consistent Efficacy and Safety of Once-Weekly Insulin Icodec in Type 2 Diabetes Mellitus
This post hoc analysis aimed to evaluate whether the efficacy and hypoglycemia risk associated with once-weekly insulin icodec vary by age, ethnicity, or race among adults with type 2 diabetes mellitus (T2DM). Data were pooled from five randomized controlled ONWARDS trials (N=3765), conducted across 35 countries, comparing once-weekly icodec with once-daily insulin regimens. Participants were […]
Gender Discrepancy in Iatrogenic Thyrotoxicosis Risk Associated with Standard Levothyroxine Dosing Algorithms
This retrospective cohort study aimed to evaluate sex-based differences in the risk of iatrogenic thyrotoxicosis associated with standard levothyroxine dosing algorithms in older adults. Conducted at Johns Hopkins University School of Medicine, the analysis included 20,724 patients aged ≥50 years who received levothyroxine between 2014 and 2024. Participants were predominantly female (n=15,894) and White (75.6% […]
Injectable Nanocomputers for Neurological Repair
The human nervous system, with its approximately 86 billion neurons and an even greater number of glial cells, represents one of the most complex and fragile networks in biology. It is the seat of consciousness, emotion, cognition, movement, and perception. When this network is disrupted — whether by trauma, genetic mutation, neurodegenerative disease, or cerebrovascular […]
The Clinical Future of Senolytics and Anti-Ageing Therapeutics
The pursuit of healthy aging has evolved from aspirational longevity research into a tangible clinical reality, with senolytics representing one of the most promising therapeutic frontiers in modern medicine. As cellular senescence emerges as a fundamental driver of age-related pathology, the clinical integration of senolytic therapies alongside comprehensive lifestyle interventions presents unprecedented opportunities for extending […]
What’s Next in Metabolic Revolution: GLP to GDF
The landscape of metabolic medicine stands at a transformative juncture, where the profound success of GLP-1 receptor agonists has not only revolutionized diabetes and obesity management but has also illuminated the intricate networks of metabolic signaling that extend far beyond glycemic control. As we witness unprecedented clinical outcomes with semaglutide, liraglutide, and their contemporaries, the […]
The Rise of Artificial Wombs
The concept of an artificial womb has long occupied the realm of science fiction and speculative thought, capturing imaginations with visions of fully external gestation. However, recent advances in biotechnology, neonatal medicine, and bioengineering have brought this once-futuristic idea to the verge of clinical reality. Artificial womb technology promises to radically transform neonatal care, reproductive […]